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6 Novel therapeutic avenues and future directions 6.1 Immunotherapy and targeted molecular treatments Recent studies have identified the calcitonin gene-related peptide (CGRP)/receptor activity modifying protein 1 (RAMP1) signaling axis as a critical player in endometriosis pathophysiology, with implications for both lesion development and pain generation ( 6.2 Ferroptosis modulation and oxidative stress control Iron overload resulting from periodic bleeding is a characteristic feature of endometriosis, which contributes to oxidative stress and plays a crucial role in the pathogenesis of endometriosis and its associated infertility

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Additionally, intratumoral injection of miR-497-5p into the CRC xenograft model reversed the growth of the tumour